The Surprising Impact of Ozempic on Sex Lives: From Cooling Off to Heating Up

Feb 14 2025

When it comes to intimacy, the effects of medications like Ozempic can be quite surprising. Miranda Shea, a critical care nurse from Northern California, experienced a sudden change in her libido after starting a regimen of compounded tirzepatide, the generic version of anti-obesity injections like Mounjaro. This abrupt aversion to sex is a lesser-known complication of GLP-1 medications, affecting both men and women and sometimes leading to issues like low testosterone levels and erectile dysfunction.

These weight loss injections, popularized by celebrities such as Oprah Winfrey and reality TV stars, can have varying impacts on dopamine levels in the body. Dopamine is the "feel good" hormone that drives individuals to engage in pleasurable activities, from indulging in treats to enjoying intimate moments. For some users like Shea, the shots can unexpectedly diminish their desire for sexual activities.

Shea, who once considered herself hyper-sexual, found her libido taking a nosedive after starting the injections. Even at her heaviest weight, she had a robust sex life, but the medication seemed to put a damper on her desires. Despite shedding 40 pounds with the help of these injections, Shea found herself losing interest in sex, a sensation she likened to the aversion some people feel towards food while on the medication.

Dr. Holly Lofton, the director of NYU Langone Health’s medical weight management program, explains that changes in libido can occur when higher doses of medications like Ozempic are introduced to a patient's evolving body. Lofton highlights that these medications can lead to a decrease in dopamine release, affecting how pleasurable activities like eating, drinking, and intimacy are perceived.

Users of tirzepatide are typically advised to start with a lower dose and gradually increase it over time. However, Lofton warns that higher doses can potentially impact libido, as the medication works more intensely in a smaller body. Some users may feel fatigued or lack the energy for activities like sex due to the medication's effects on glucose levels.

Individual responses to these injections can vary significantly. For Shea, reducing her dosage helped restore her libido, while others like Christine found that increasing the strength of their shots reignited their passion. Christine, a sales executive and content creator, experienced a resurgence in her sex drive after upping her dose, shedding pounds, and feeling more energized.

Research from the University of Florence in Italy suggests that some users may experience a heightened libido due to GLP-1 medications. Factors such as weight loss, insulin control, and improved mental health can contribute to these changes. Caley Svensson, a mother of three and decor influencer from New Jersey, credits her improved libido to the positive impact of Mounjaro on her mental health.

Prior to starting the injections, Svensson struggled with obesity and depression. However, after shedding nearly 100 pounds with the help of the injections, she regained her confidence and felt more comfortable and passionate in the bedroom. The weight loss injections not only transformed her physical appearance but also boosted her self-esteem and desire for intimacy.

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